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Ativan, sold under the generic name of Lorazepam, is a prescription drug that is an antianxiety medication in the benzodiazepine family, the same family that includes diazepam, alprazolam, clonazepam, flurazepam, and others. Ativan and all other benzodiazepines work by enhancing the effects of gamma-aminobutyric acid in the brain. GABA is a neurotransmitter, a chemical that nerves in the brain use to send messages to one channel to another another. GABA inhibits activity in different of the nerves of the brain, and it is thought that this excessive activity is what causes anxiety or other psychological disorders. Because Ativan is extracted from the blood more rapidly than many other benzodiazepines, there is less chance that Ativan concentrations in blood will reach high levels and become toxic. Ativan has lesser interactions with other medications than most of the other benzodiazepines.
Ativan is indicated for the management of anxiety disorders, the short-term relief of the symptoms of anxiety or anxiety associated with depression. The effectiveness of Ativan, or other benzodiazepines, has not been adequately studied for treatment beyond 4 months. Ativan also has been shown to be more effective for improving sleep in people with insomnia, for panic attacks, and as an adjunct to prevent nausea and vomiting in patients receiving cancer chemotherapy.
As far as dosing, the dosage of Ativan is tailored to the for the patient's needs. Scheduled doses, given twice or three times daily, are sometimes indicated for persons with continuous anxiety or at bedtime for insomnia. Alternatively, Ativan may be prescribed on as as necessary basis, the doctor instructing the patient to take Ativan when he/she feels anxious. The medication should be kept at room temperature, are taken orally, and come in sizes of .5, 1, and 2 mg.
Ativan and all benzodiazepines, interact with all other medications and drugs that slow the brain's processes such as alcohol, barbiturates, and narcotics. There have been cases of marked sedation when Ativan was given to patients administering the tranquilizer loxapine; it is unclear if there is a medication interaction at all, but concern is warranted. Ativan and other benzodiazepines have been related with fetal damage, including congenital malformations, when taken by pregnant women in their first trimester. Ativan is should avoided if at all possible in the first trimester and probably throughout pregnancy.